When we get cuts and scrapes or minor injuries to our skin, we try some home remedies to treat it. But what about more serious wounds, the kind that involves stitches or a hospital stay? Larger wounds may take longer to heal, and sometimes stitches are needed. Also, there are some types of wounds that not only close very slowly but also keep on opening up or don’t heal at all. This is usually a result of circulation problems or what they called ‘diabetes’. Those wounds are considered “chronic” by doctors. Chronic wounds don’t heal within eight weeks and these poorly healing wounds are more common on the feet or lower legs.
Since treatment for chronic wounds often takes a long time and can be painful sometimes, people experiencing these may feel very uncomfortable or embarrassed and withdraw from social situations. This makes good emotional, practical and medical support so important – from friends and family, as well as from the family doctor, wound care specialists and home care nurses. Talking with them about the treatment, the symptoms, and their effects can help you find out how best to care for the wound.
Whether, minor or chronic wounds, both are important to be treated with care. For instance, the bacteria can get into the wounds and become infected and the tissue may even die. Without the treatment, the germs may spread, leading to blood poisoning (septicemia). If the worst comes to the worst, the affected part of the body – for example, the foot – may have to be amputated (cut off).
To find solution on above-mentioned matters, there were scientific efforts done. There’s a study performed by the National Institutes of Health (one of the world’s foremost medical research centers) that examined the wound healing efficiency of Spirulina platensis (‘Blue-green alga’ or ‘Spirulina platensis’ is a well-known nutri-supplement with high nutritional and medicinal properties), at various solvent extracts using in vitro scratch assay on ‘human dermal fibroblast’ cells (HDF- are responsible for producing the extracellular matrix forming the connective tissue of the skin, and play a crucial role during wound healing). Various gradient solvent extracts (50 µg/ml of methanolic, ethanolic and aqueous extracts) from Spirulina platensis were treated on HDF cells to acquire its wound healing properties through scratch assay and in this investigation they used allantoin, as a positive control to compare efficacy among the phytoextracts. Interestingly, aqueous extract was found to stimulate proliferation and migration of HDF cells at given concentrations and enhanced closure rate of wound area within 24 hours after treatment. Methanolic and ethanolic extracts have shown a proliferative effect, however, these extracts did not aid in the migration and closure of wound area when compared to aqueous extract. Based on a phytochemical profile of the plant extracts analyzed by LC-MS/MS, it was shown that compounds supposedly involved in accelerating wound healing are cinnamic acid, narigenin, kaempferol, temsirolimus, phosphatidylserine isomeric derivatives and sulphoquinovosyl diacylglycerol. Check out formula f1 live stream. The findings concluded that blue-green algae may pose potential biomedical application to treat various chronic wounds especially in diabetes mellitus patients.
Another study from Hindawi Journals also shows the potential of Spirulina to facilitate skin regeneration to cutaneous wounds. Spirulina, blue-green algae that has antioxidant and anti-inflammatory activities, has been used to relieve such ROS stress. In the study, Spirulina extract loaded PCL (Spirulina-PCL) nanofiber was evaluated as a cutaneous wound dressing in view of antioxidative mechanism. In addition to increasing fibroblast viability, the Spirulina extract and its dressing modulated intra- and extracellular ROS by enhancing antioxidant mechanism of fibroblast under oxidative stress. Finally, in vivo assays confirmed that Spirulina-PCL helps regenerate wounds and enhance regeneration. Taken together, the results of this study indicate that Spirulina and nanofiber have the potential for application to cutaneous wound to facilitate skin regeneration.
Furthermore, a published scientific study from the Journal of Medicinal Plants Research, evaluated the influence of crude Spirulina extract and C-phycocyanin (C-PC) isolated from the crude Spirulina extract on cultured human keratinocyte, using in vitro and in vivo models of wound healing. Spirulina has been used as a nutraceutical and source of potential pharmaceuticals; however, it is not known which component of the cyanobacteria is effective for wound healing. In in vitro model, cultured human keratinocyte were used to investigate the effects of crude Spirulina extract (PSE) and C-phycocyanin (C-PC) extracts on processes involved in keratinocyte proliferation, regeneration and migration. Keratinocyte proliferation and regeneration were monitored by the colorimetric (MTT) assay and migration was monitored in relation to the closure of a denuded area scratched in a confluent monolayer. On the other hand, in in vivo model using Sprague-Dawley male rats, the effects of PSE and C-PC on tissue regeneration were investigated. Results of in vivo wound healing study were monitored by means of histological examinations. PSE extract showed the best growth stimulation at 33.5 µg/mL dose of treatment, which revealed a cell viability ranging from 100 to 270% after 72 h. Cell viability was also good for C-PC and was measured as high as 213%. Cell viability and proliferation difference between PSE and C-PC were observed not to be significant (p > 0.05) at the range of doses (33.5 to 0.0335 µg/mL) studied. In in vivo efficiency of the PSE and C–PC, it was observed that 1.25% C-PC has a better effect on the 7th day compared to other preparations.
SPIRULINA – your Wound Care!
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